Why would mutation of a tyrosine residue to glutamate in the intracellular portion of a growth factor receptor lead to increased tumor formation

Answers

Answer 1

Answer:

this mutation leads to a constitutively active state where the receptor can not be inactivated by dephosphorylation  

Explanation:

Phosphorylation is a posttranslational modification that usually occurs at the side chains of serine, tyrosine and threonine residues, thereby regulating protein function. Phosphomimetic amino acids are substitutions (mutations) able to mimic the phosphorylated form of the protein, resulting in constitutive activation/inactivation of the corresponding protein. In this case, it is expected that the substitution of tyrosine to glutamate gives rise to a constitutively active state of the receptor by replacing tyrosine with a phosphomimetic residue.


Related Questions

Help me please thanks the first one

Answers

Answer:

7683.2 Joules

Explanation:

We can calculate potential energy using the equation that is used to calculate the work done by a conservative force, in this case, gravity.

U(x)gravity = mgy

U represents potential energy, m is mass, g is gravity, and y is the height.

U(x) = (80 kg)(9.8 m/s^2)(9.8m)

Potential Energy = 7683.2 Joules

look at the picture

Answers

Answer:

What was the question of it

5. The double helix model of DNA explained Chargaff's rules
because
A. adenine could hydrogen-bond with thymine and
guanine could hydrogen-bond with cytosine to hold the
helix together.
B. a helix repeats itself many times over, so the four bases
in DNA can repeat themselves many times.
C. adenine and thymine are found in one strand of the
double helix and guanine and cytosine are found in the
other strand.
OD. adenine could change places with thymine while
munninn anuld chanannhan with

Answers

Answer:A adenine could hydrogen-bond with thymine and guanine could hydrogen bond with cytosine to hold the helix together

Explanation:

The double helix model of DNA explained Chargaff's rules because adenine could hydrogen-bond with thymine and guanine could hydrogen-bond with cytosine to hold the helix together. The correct option is A.

What is Chargaff's rule?

According to Chargaff's criteria, guanine and cytosine should be equal in amount in the DNA of every species and organism, and adenine and thymine should be equal in amount.

Additionally, the purine and pyrimidine bases should be in a 1:1 stoichiometric ratio.

The ratio of the several nitrogenous bases present inside the DNA molecule is described. It assists in figuring out the makeup and structure of DNA in various species.

Because adenine could hydrogen bond with thymine and guanine could hydrogen bond with cytosine to maintain the helix together, the double helix model of DNA provided an explanation for Chargaff's rules.

Thus, the correct option is A.

For more details regarding Chargaff's rule, visit:

https://brainly.com/question/14083251

#SPJ5

Cells in the body needs what for energy

Answers

Answer:

Mostly glucose

Explanation:

Answer:

Different Cell Types Require Different Fuel Molecules. Red blood cells rely on glucose for energy and convert glucose to lactate. The brain uses glucose and ketone bodies for energy. Muscle cells use fatty acids, glucose, and amino acids as energy sources.

why are there so many stages in meiosis?

Answers

Answer:

In many ways meiosis is a lot like mitosis since cell division occurs twice during meiosis one starting cell can produce four gametes ( egg or sperm ) in each round of division cells go though four stages prophase, metaphase anaphase, and telophase

Explanation:

Evaluate the evolutionary benefits of regulating an internal variable, such as body temperature, versus the cost.

Answers

Answer:

The benefits of being able to regulate the internal body temperature are many and it is considered a beneficial evolutionary character, since in this way the living organism is better maintained in relation to the environment, and it achieves better balance.

Reptiles cannot control their internal temperature, it depends on the external one, that is why to warm their body they need to be in the sun, and to cool down in the shade or in temperate places.

This is a little evolutionary characteristic since the environment is very changeable and the right or ideal temperature for the organism could not be controlled.

Explanation:

Faced with climatic catastrophes or extreme situations, living organisms cannot depend on the great climatic variants, in very cold situations one enters hypothermia and in very hot conditions the proteins are systematically denatured, entering a thermal shock.

explain how water properties help get water from the roots of plants to leaves

Answers

Answer:

In order for water to move through the plant from the soil to the air (a process called transpiration), soil must be > root > stem > leaf > atmosphere. ... Because of this difference in water potential, water will move from the soil into a plant's root cells via the process of osmosis.

Explanation:

I need help with this question pls answer.

Answers

Answer:

I think its picture B

Explanation:

if you do not contact your loan servicer to select another option, your Federal student loans will default to standard repayment, which has a term of

Answers

Answer: 10 years

Explanation:

When the student is not able to pay the loan on regular basis then the repayment plan is available that is called standard repayment plan. It is a kind of default plan for all and most kind of student loans. In this the monthly payment is broken down of an amount of $50 which is the minimum amount for loan pay for the duration of maximum 10 years. This payment plan helps to lower down the interest money on the payments.

I need this to finish break out room. Unscramble and enter the escape word hint it is what you do when you eat. Letter are ell ts gi

Answers

A n s w e r:

Digest, maybe

Answer:

u got snap, or ig since u go to my school,and we can help eachother with our work it u want

ideas on a science experiment that has to do with marine science?​

Answers

Answer:

SALT WATER DENSITY

LAYERS OF THE OCEAN

SHARK BUOYANCY

HOW WHALES STAY WARM

TIDE POOL

WATER/SHORELINE EROSION

OCEAN BOTTLE

CORNMEAL CURRENTS

DEEP-WATER CURRENTS

PENGUIN CAMO

Explanation:

A farmer has been trying to increase his crop yield for the last 10 years by
adding about 25% more fertilizer to his crops than he needs. What will most
likely result from this action?
Select one:
a. Increased crop yields.
b. Air pollution from the excess fertilizers
c. Soil degradation form the excess fertilizers
d. The additional fertilizer will have little to no impact.

Answers

Answer:

The correct answer is - b. Air pollution from the excess fertilizers

Explanation:

In long term using excess amount of fertilizer than requirement will lead to several condition such a soil acidity, soil degradation, soil leacing, eutrophication of waterways and many but more improtant is green house gases and air pollution.

Using the excess amount of fertilizer does not help in increasing crop yield but gives negative impact. Using fertilizer more than requirement wil lead to release of toxic and harmful gases in atomosphere and fuming.

Describe endocytosis, phagocytosis, pinocytosis, and exocytosis.

Answers

Answer:

Endocytosis: Endocytosis is the process by which cells take in substances from outside of the cell by engulfing them in a vesicle.

Phagocytosis: Phagocytosis, process by which certain living cells called phagocytes ingest or engulf other cells or particles.

Pinocytosis: Pinocytosis, a process by which liquid droplets are ingested by living cells.

Exocytosis: Exocytosis is the process by which a large amount of molecules are released; thus it is a form of bulk transport.

Explanation:


Explain how the stomach Depends on other body systems to carry out its role in breaking down food molecules.

Answers

The whole body works together, as a “team.”If one of the parts of the body won’t work together as a team, everything will get messed up. The stomach muscles churn and mix the food with digestive juices that have acids and enzymes, breaking it into much smaller, digestible pieces. An acidic environment is needed for the digestion that takes place in the stomach.

Precipitation falls to the ground and eventually ends up in the ocean. Which of the following is the most direct way for the water to get from the soil to the ocean? A. By way of a recharge zone with a low percolation rate B. By way of a closed watershed C. By way of an open watershed D. By way of thermohaline circulation within an aquifer​

Answers

Answer: D. By way of thermohaline circulation within an aquifer​

Explanation: The most direct way for the water to get from the soil to the ocean is by way of a recharge zone with a low percolation rate. Human activity in the recharge zone can limit the amount water that reaches the aquifer.

which wall structures are found in plant cells but not in animal cells check all that apply
cell wall
cell membrane
endoplasmic reticulum
nucleus
chloroplasts
mitochondria​

Answers

Answer:

cell wall, chloroplasts

Explanation:

no explanation, just the correct answer

Answer:

Options: A and E

Explanation:It was correct on edg 2021, Have a blessed day.

what do microbiologist do? why are their contributions imported to science? pls help!

Answers

They use there knowledge to prevent or treat disease, develop new technologies and improve our lives in general. Their contributions imported to science because it helps us with things that are ill to our body, like diseases.

Humans always have a negative impact on the environment.


Please select the best answer from the choices provided

T
F

Answers

False would be the answer
False bc that’s not how it always is

Desert plants and animals are adapted to the lack of what and high

Answers

The two main adaptations that desert animals must make are how to deal with lack of water and how to deal with extremes in temperature. Many desert animals avoid the heat of the desert by simply staying out of it as much as possible

Answer:

lack of water and high concentration of heat and dryness

Explanation:

Deserts don't get that much rainfall, so desert wildlife are adapted to survive in such a dry climate. Take the camel, for instance, it can store three bathtubs of water in it's hump, so it can go a very long time without water. And without that rainfall, the desert is dry and, usually, very hot. Animals have adapted to this by only coming out in the nighttime when it's cooler.

hope this helped:)

Only answer if you know the answer

Answers

The correct answer is "Two identical DNA molecules are made that contain one original strand and one paired strand."

Explanation:

The word "conserve" refers to the action of preserving an element. Moreover, the prefix "semi" refers to partial. In this context, DNA replication can be considered as a semi conservative process because the original DNA is partially preserved. This is explained in "Each of the two daughter molecules made during replication contain one strand from the parent molecule and one new strand" because this excerpt shows how in the process each of the cells resulting has at least 50% of the DNA of the original cell. This implies replication does not lead to a completely new cell as part of the genetic material is kept. According to this, this process can be considered as semiconservative because "Two identical DNA molecules are made that contain one original strand and one paired strand."

Morphine 4mg IV push is ordered. The vial states 10mg/mL. How many mL will you give?

Answers

Answer:

If a vial of morphine has 10 mg/mL, and a dose of 4 mg is required to be administered intravenously, 04 mL must be administered to fulfill the indication.

Explanation:

Morphine is a drug, an opioid derivative, with a potent analgesic and sedative effect. Its use is intended for acute or chronic severe pain, mainly related to cardiovascular disease, cancer or severe trauma.

One vial of morphine vial has a concentration of 10 mg/mL, so if 4 mg is required, a simple calculation must be made:

Morphine: 10 mg ------------ 1 mL

Dose:          4 mg ------------ X

X = (4 x 1)/ 10

X = 4/10

X = 0.4 mL

To administer 4 mg of intravenous morphine, 0.4 mL of the injection should be used.

From Earth’s atmosphere, where can the carbon atom go next?

Answers

The carbon atom can go to the plants on the Land.
The carbon atom would then cycle to the plants, because the plants use carbon to make food and stay alive :))

Roundworms
Type of skeleton (ENdoskeleton, EXoskeleton, or None)
Type of appendages (Jointed, Not Jointed, or Absent)
Segmentation (Present or Absent)
Type of symmetry (Radial, Bilateral, or None)

Answers

Answer:

Think about it. Worms move with MUSCLES. So the first answer is None.

The appendage of a roundworm is not present.

How do you think worms turn and move? They are segmented. The symmetry  of a worm is Bilateral.

Explanation:

I'm doing the assignment myself. Look up the answers and use common logic.

in what form is carbon found in the atmosphere?

Answers

Answer:

carbon dioxide(CO2)

Methane gas(CH4)

Explanation:

Answer:

CO2

Explanation:

Need help will mark Brainliest

Answers

Answer: the secondary response to Antigen A is greater because the lymphocytes remember the antigen

10. What enzyme unzips or breaks apart DNA for replication?
A. Helicase
B. Ligase
C. Polymerase
D. Okazaki

Answers

The answer is A which is helicase

Answer:

a. Helicase Helicase the double helix bond is broken.

Most of a cell's growth and activity occurs in the__
phase.

Answers

Answer:

The mitachondria.

Explanation:

it is a place in the cells proteins which build and replace each other to fix cells or make new ones.

The answer is mitochondria

The picture shows respiratory epithelium in the lungs. The cilia, or fingerlike projections are MOST LIKELY there to
A)
move liquid.
B)
catch debris.
C)
secrete mucus.
D)
transmit impulses

Answers

Answer:

B. catch debris in the lungs

B. Catch debris would be the answer

Light rays from the sun are called:
solar energy
heat energy
chemical energy​

Answers

Answer:

solar energy aka elctromagnetic energy

Explanation:

Answer:

Solar energy

Explanation:

Which statement is best represented by the diagram?
All carbon is in the form of carbon dioxide,

Carbon can exist in many forms, but the total amount of carbon stays the same.

The amount of carbon in the cycle can increase or decrease based on the number of factories present.

Only living things release carbon dioxide into the atmosphere.

Answers

The second one makes sense to me
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